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Peptide record

TPDB72649

Neurotoxin standard
59 amino acids
Basic Information
3D PDB MODEL
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TPDB72649
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 59-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
ADNHARVAGPRAVASGRYATEKAFLQMMTRGSCGLPCHENRRCGWACYCDDGICKPLRV
Physicochemical Analysis
C271H432N90O79S8
A
6471.45
8.58
11
5
21
+4
10.77
-0.388
54.75
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
8855
136.83
15
Residue Composition
number
8
A
7
R
2
N
3
D
6
C
2
E
1
Q
6
G
2
H
1
I
3
L
2
K
2
M
1
F
3
P
2
S
2
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 8 R: 7 N: 2 D: 3 C: 6 E: 2 Q: 1 G: 6 H: 2 I: 1 L: 3 K: 2 M: 2 F: 1 P: 3 S: 2 T: 2 W: 1 Y: 2 V: 3
Chemical Descriptors
59
C271H432N90O79S8
6471.45
8.58
+4
10.77
-0.388
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Crassispirid snail peptide that induces sleep-like symptoms in young mice (12 and 14 days) and hyperactivity in older mice (16 days), when intracranially injected. {ECO:0000269|PubMed:21939682}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crassispira cerithina (Sea snail) (Turridrupa cerithina)
Neurotoxin
Crassispirid snail peptide that induces sleep-like symptoms in young mice (12 and 14 days) and hyperactivity in older mice (16 days), when intracranially injected..
Crassipeptide cce9a (Cce9.1)
other
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Crassipeptide cce9a (Cce9.1)
TISSUE SPECIFICITY: Expressed by the venom duct.
other