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Peptide record

TPDB72643

Neurotoxin standard
77 amino acids
Basic Information
3D PDB MODEL
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TPDB72643
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 77-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKVFSFTVVVVMILSLSAFVLAGDEGDVMKKIVAMEEAVEERACLAEYQKCEGSTVPCCPGLSCSAGRFRKTKLCTK
Physicochemical Analysis
C364H600N94O108S10
NHW
V
8341.93
7.62
10
9
34
+1
16.54
0.394
87.27
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
22.36
18
Residue Composition
number
7
A
3
R
0
N
2
D
6
C
7
E
1
Q
5
G
0
H
2
I
6
L
7
K
4
M
4
F
2
P
6
S
4
T
0
W
1
Y
10
V
Amino Acid Distribution
A: 7 R: 3 N: 0 D: 2 C: 6 E: 7 Q: 1 G: 5 H: 0 I: 2 L: 6 K: 7 M: 4 F: 4 P: 2 S: 6 T: 4 W: 0 Y: 1 V: 10
Chemical Descriptors
77
C364H600N94O108S10
8341.93
7.62
+1
16.54
0.394
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits Kv11.1/KCNH2/ERG1, Kv1.1/KCNA1 and Kv1.3/KCNA3 voltage-gated potassium channels and Nav1.7/SCN9A voltage-gated sodium channels (PubMed:29483648). In vivo, intracranial injection into mice causes lack of coordination for 10 minutes, followed by fast recovery. {ECO:0000269|PubMed:15246762}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits Kv11.1/KCNH2/ERG1, Kv1.1/KCNA1 and Kv1.3/KCNA3 voltage-gated potassium channels and Nav1.7/SCN9A voltage-gated sodium channels (PubMed:29483648). In vivo, intracranial injection into mice causes lack of coordination for 10 minutes, followed by fast recovery..
U11-hexatoxin-Mg1a (U11-HXTX-Mg1a) (Neurotoxin magi-10)
spider
Neurotoxin 02 (plectoxin) family, 04 (U16-lycotoxin) subfamily
Evidence at protein level
Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15246762}.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family, 04 (U16-lycotoxin) subfamily
U11-hexatoxin-Mg1a (U11-HXTX-Mg1a) (Neurotoxin magi-10)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15246762}.
spider