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Peptide record

TPDB72640

Neurotoxin standard
71 amino acids
Basic Information
3D PDB MODEL
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TPDB72640
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 71-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MMSKLGVLLCIFLVLFPMATLQLDGDQTADRHADQRGQDLTEQQRNSKRVLKKRDWEYHAHPKPNSFWTLV
Physicochemical Analysis
C370H585N107O104S4
L
8324.61
9.50
13
8
28
+2
14.68
-0.546
82.39
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
150.04
17
Residue Composition
number
4
A
5
R
2
N
6
D
1
C
2
E
6
Q
3
G
3
H
1
I
10
L
5
K
3
M
3
F
3
P
3
S
4
T
2
W
1
Y
4
V
Amino Acid Distribution
A: 4 R: 5 N: 2 D: 6 C: 1 E: 2 Q: 6 G: 3 H: 3 I: 1 L: 10 K: 5 M: 3 F: 3 P: 3 S: 3 T: 4 W: 2 Y: 1 V: 4
Chemical Descriptors
71
C370H585N107O104S4
8324.61
9.50
+2
14.68
-0.546
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: May act as a neurotoxin.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus marmoreus (Marble cone)
Neurotoxin
May act as a neurotoxin.
Conomarphin-Mr3 (Conomarphin) (Marmophine) (Mr-1)
cone snail
Conotoxin M superfamily
Evidence at protein level
3D-structure Cleavage on pair of basic residues D-amino acid Direct protein sequencing Hydroxylation Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18355315}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: May act as a neurotoxin.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus imperialis (Imperial cone)
Neurotoxin
May act as a neurotoxin.
Im-conomarphin
cone snail
Conotoxin A superfamily
Evidence at transcript level
Cleavage on pair of basic residues D-amino acid Hydroxylation Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
3D-structure Cleavage on pair of basic residues D-amino acid Direct protein sequencing Hydroxylation Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at protein level Evidence at transcript level
Conotoxin M superfamily Conotoxin A superfamily
Conomarphin-Mr3 (Conomarphin) (Marmophine) (Mr-1) Im-conomarphin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18355315}. TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail