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Peptide record

TPDB72636

Neurotoxin standard
71 amino acids
Basic Information
3D PDB MODEL
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TPDB72636
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 71-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSQNSITSYKMGFAKHFFLFAVLLCATAMYSVAEPAQERLIESIACMQKGLPCMEHVDCCHGVCDSLFCLY
Physicochemical Analysis
C350H539N87O99S12
W
ACL
7934.37
5.78
7
6
34
-2
4.29
0.496
81.13
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
61.06
22
Residue Composition
number
7
A
1
R
1
N
2
D
7
C
4
E
3
Q
3
G
3
H
3
I
7
L
3
K
5
M
5
F
2
P
6
S
2
T
0
W
3
Y
4
V
Amino Acid Distribution
A: 7 R: 1 N: 1 D: 2 C: 7 E: 4 Q: 3 G: 3 H: 3 I: 3 L: 7 K: 3 M: 5 F: 5 P: 2 S: 6 T: 2 W: 0 Y: 3 V: 4
Chemical Descriptors
71
C350H539N87O99S12
7934.37
5.78
-2
4.29
0.496
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable insect neurotoxin with ion channel impairing activity (Probable). Does not show activity on 45 human receptors from 9 families (5-hydroxytryptamine, adrenergic, dopamine, muscarinic, histamine, neurotransmitter, opioid, sigma, and gaba(A) receptors) (PubMed:27227898). In vivo, when mixed with U3-SYTX-Sth1a does not cause paralytic or lethal activity when injected into crickets (PubMed:27227898). It is noteworthy that crickets are evolutionarily distant from prey species (PubMed:27227898). {ECO:0000269|PubMed:27227898}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scytodes thoracica (Spitting spider) (Aranea thoracica)
Neurotoxin Ion channel impairing toxin
Probable insect neurotoxin with ion channel impairing activity (Probable). Does not show activity on 45 human receptors from 9 families (5-hydroxytryptamine, adrenergic, dopamine, muscarinic, histamine, neurotransmitter, opioid, sigma, and gaba(A) receptors) (PubMed:27227898).
U3-scytotoxin-Sth1h (U3-SYTX-Sth1h) (U3-Sth1h)
spider
Evidence at protein level
3D-structure Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24303891}.
Additional Detail Fields 6 fields
3D-structure Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
U3-scytotoxin-Sth1h (U3-SYTX-Sth1h) (U3-Sth1h)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24303891}.
spider