Back to search

Peptide record

TPDB72633

Neurotoxin standard
60 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72633
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 60-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSNMPVLIITLLLFSMYISTAAQKPTEIKCRYPADCHIMCRKVTGRAEGKCMNGKCTCYY
Physicochemical Analysis
C295H481N79O82S11
W
C
6799.20
8.83
9
3
25
+5
5.69
0.105
74.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6335
93.17
21
Residue Composition
number
4
A
3
R
2
N
1
D
6
C
2
E
1
Q
3
G
1
H
5
I
4
L
5
K
5
M
1
F
3
P
3
S
5
T
0
W
4
Y
2
V
Amino Acid Distribution
A: 4 R: 3 N: 2 D: 1 C: 6 E: 2 Q: 1 G: 3 H: 1 I: 5 L: 4 K: 5 M: 5 F: 1 P: 3 S: 3 T: 5 W: 0 Y: 4 V: 2
Chemical Descriptors
60
C295H481N79O82S11
6799.20
8.83
+5
5.69
0.105
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lychas mucronatus (Chinese swimming scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits voltage-gated potassium channels..
Potassium channel toxin alpha-KTx 12.7
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at transcript level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily
Potassium channel toxin alpha-KTx 12.7
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion