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Peptide record

TPDB72631

Neurotoxin standard
115 amino acids
Basic Information
3D PDB MODEL
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TPDB72631
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 115-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKVAVIILSILVLAAASESIEEYREDFSRPNAMERSANDWIPTAPSAVERSADFAVEELERATCAGQDKPCKETCDCCGERGECVCALSYEGKYRCICRQGYVWIAWYKLASCKK
Physicochemical Analysis
C556H877N153O173S12
H
A
12857.72
4.86
15
18
47
-3
28.30
-0.192
74.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
24575
191.13
31
Residue Composition
number
15
A
8
R
2
N
5
D
10
C
13
E
2
Q
5
G
0
H
7
I
6
L
7
K
2
M
2
F
4
P
9
S
3
T
3
W
5
Y
7
V
Amino Acid Distribution
A: 15 R: 8 N: 2 D: 5 C: 10 E: 13 Q: 2 G: 5 H: 0 I: 7 L: 6 K: 7 M: 2 F: 2 P: 4 S: 9 T: 3 W: 3 Y: 5 V: 7
Chemical Descriptors
115
C556H877N153O173S12
12857.72
4.86
-3
28.30
-0.192
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated sodium channels (Nav). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Blocks voltage-gated sodium channels (Nav)..
U2-ctenitoxin-Pn1b (U2-CNTX-Pn1b) (Neurotoxin Pn2-1A)
spider
Neurotoxin 03 (Tx2) family, 04 subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Neurotoxin 03 (Tx2) family, 04 subfamily
U2-ctenitoxin-Pn1b (U2-CNTX-Pn1b) (Neurotoxin Pn2-1A)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider