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Peptide record

TPDB72617

Neurotoxin standard
139 amino acids
Basic Information
3D PDB MODEL
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TPDB72617
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 139-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
AVCVSLLGAANIPPHPFNLINFMKMIRYTIPCEKTWGEYVDYGCYCGVGGSGRPIDALDRCCYVHDNCYGDAEKKHKCNPKMQSYSYKLTKRTTSAMVPQVLVHVLSVIVTARQPSASAILNTSSGTRILTPRDIADDI
Physicochemical Analysis
C673H1068N186O198S12
V
15317.73
8.29
19
11
55
+4
20.75
-0.090
83.45
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
17920
116.99
44
Residue Composition
number
10
A
7
R
6
N
8
D
8
C
3
E
3
Q
9
G
4
H
10
I
9
L
8
K
4
M
2
F
9
P
10
S
9
T
1
W
8
Y
11
V
Amino Acid Distribution
A: 10 R: 7 N: 6 D: 8 C: 8 E: 3 Q: 3 G: 9 H: 4 I: 10 L: 9 K: 8 M: 4 F: 2 P: 9 S: 10 T: 9 W: 1 Y: 8 V: 11
Chemical Descriptors
139
C673H1068N186O198S12
15317.73
8.29
+4
20.75
-0.090
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity). {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bungarus candidus (Malayan krait)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity)..
Basic phospholipase A2 beta-bungarotoxin A2 chain (Beta-BuTX A2 chain) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group I subfamily, D49 sub-subfamily
Evidence at transcript level
Calcium Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at transcript level
Phospholipase A2 family, Group I subfamily, D49 sub-subfamily
Basic phospholipase A2 beta-bungarotoxin A2 chain (Beta-BuTX A2 chain) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
snake