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Peptide record

TPDB72611

Neurotoxin standard
56 amino acids
Basic Information
3D PDB MODEL
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TPDB72611
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 56-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MFKQLILLALAAVFLLINISSAEPAAEPNANAEPLAEASAEPRIKIGLFDQLSKLG
Physicochemical Analysis
C271H443N67O78S1
CHTWY
A
5919.96
4.50
4
6
31
-2
7.30
0.530
129.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
9
Residue Composition
number
11
A
1
R
3
N
1
D
0
C
5
E
2
Q
2
G
0
H
5
I
10
L
3
K
1
M
3
F
4
P
4
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 11 R: 1 N: 3 D: 1 C: 0 E: 5 Q: 2 G: 2 H: 0 I: 5 L: 10 K: 3 M: 1 F: 3 P: 4 S: 4 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
56
C271H443N67O78S1
5919.96
4.50
-2
7.30
0.530
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits sodium channels (Nav) inactivation. Shows two types of inhibitory activities on channels. Inhibition of hNav1.6/SCN8A shows a large increase in the steady-state current component without any increase in the slow component, whereas inhibition of hNav1.1/SCN1A, hNav1.2/SCN2A, hNav1.3/SCN3A and hNav1.7/SCN9A shows a large increase in the slow component with only a small steady-state component (PubMed:20059541). Is 5-fold less potent than beta-PMTX for inducing repetitive action potentials in lobster neuromuscular junctions. {ECO:0000269|PubMed:10886337, ECO:0000269|PubMed:20059541, ECO:0000269|PubMed:9756356}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anoplius samariensis (Solitary wasp)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits sodium channels (Nav) inactivation. Shows two types of inhibitory activities on channels.
Alpha-pompilidotoxin (Alpha-PMTX)
insect
Evidence at protein level
Amidation Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Alpha-pompilidotoxin (Alpha-PMTX)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
insect