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Peptide record

TPDB72604

Neurotoxin standard
112 amino acids
Basic Information
3D PDB MODEL
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TPDB72604
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 112-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MRIWSLTRILTFIVIFNFAEAGGECMKKCDSPDMIREIFTRCTMVKRDTQFSENSGHLIPKRSVVADNKCENSLRREIACGQCRDKVKTDGYFYECCTSDSTFKKCQDLLHK
Physicochemical Analysis
C560H897N161O168S13
K
12990.04
8.21
21
15
37
+4
28.73
-0.419
65.27
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8980
69.13
34
Residue Composition
number
4
A
9
R
4
N
8
D
9
C
7
E
3
Q
5
G
2
H
8
I
6
L
10
K
4
M
7
F
2
P
8
S
8
T
1
W
2
Y
5
V
Amino Acid Distribution
A: 4 R: 9 N: 4 D: 8 C: 9 E: 7 Q: 3 G: 5 H: 2 I: 8 L: 6 K: 10 M: 4 F: 7 P: 2 S: 8 T: 8 W: 1 Y: 2 V: 5
Chemical Descriptors
112
C560H897N161O168S13
12990.04
8.21
+4
28.73
-0.419
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin that inhibits voltage-gated sodium channel with a preference for hNav1.7/SCN9A (IC(50)=25.4 nM) over hNav1.1/SCN1A (IC(50)=4.1 uM), hNav1.2/SCN2A (IC(50)=813 nM), and hNav1.6/SCN8A (IC(50)=15.2 uM) (PubMed:24082113). Is an effective analgesic in rodent pain models, since it is several-fold more effective than morphine in a rodent model of formalin-induced pain and is equipotent with morphine in its ability to reduce thermal and acid-induced pain (PubMed:24082113). In addition, this peptide shows a high level of resistance to proteases and a high thermal stability that may be explained by its predominant composition of alpha-helices (PubMed:24082113). {ECO:0000269|PubMed:24082113}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that inhibits voltage-gated sodium channel with a preference for hNav1.7/SCN9A (IC(50)=25.4 nM) over hNav1.1/SCN1A (IC(50)=4.1 uM), hNav1.2/SCN2A (IC(50)=813 nM), and hNav1.6/SCN8A (IC(50)=15.2 uM) (PubMed:24082113). Is an effective analgesic in rodent pain models, since it is several-fold more effective than morphine in a rodent model of formalin-induced pain and is equipotent with morphine in its ability to reduce thermal and acid-induced pain (PubMed:24082113).
Mu-scoloptoxin(03)-Ssm2a (Mu-SLPTX(03)-Ssm2a) (Mu-scoloptoxin-Ssm6a) (Mu-SLPTX-Ssm6a)
other
Scoloptoxin-03 family
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24082113}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Scoloptoxin-03 family
Mu-scoloptoxin(03)-Ssm2a (Mu-SLPTX(03)-Ssm2a) (Mu-scoloptoxin-Ssm6a) (Mu-SLPTX-Ssm6a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24082113}.
other