TPDB

3D PDB MODEL

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TPDB ID TPDB72602

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 307-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MLKGRNLLDPMDFSLEELEEVFKLADEIIEEPEKFLHVCDGKILATLFYEPSTRTRFSFEAAMLRLGGQVIGFSEPNSSSVAKGESVADTIRTVGCYADIAAMRHPKEGAPAIAAMYSDIPVINAGDGSHQHPTQTLTDLLTIRSLKGDLSNLTIGCCGDLKFGRTVHSLVKALSRYKNNKFVFMSPEELKIPDYIRKEILEKNNIEYKEISKMEDAMAELDILYMTRVQRERFFNEDDYVRLKDSYILDGEKMKYAKKDMMVLHPLPRVNEIAYEIDQDPRGCYFKQAKYGMYVRMALIAKLLGVR

FASTA

>TPDB72602|Neurotoxin|length=307
MLKGRNLLDPMDFSLEELEEVFKLADEIIEEPEKFLHVCDGKILATLFYEPSTRTRFSFEAAMLRLGGQVIGFSEPNSSSVAKGESVADTIRTVGCYADIAAMRHPKEGAPAIAAMYSDIPVINAGDGSHQHPTQTLTDLLTIRSLKGDLSNLTIGCCGDLKFGRTVHSLVKALSRYKNNKFVFMSPEELKIPDYIRKEILEKNNIEYKEISKMEDAMAELDILYMTRVQRERFFNEDDYVRLKDSYILDGEKMKYAKKDMMVLHPLPRVNEIAYEIDQDPRGCYFKQAKYGMYVRMALIAKLLGVR

Formula C1558H2477N413O461S19

Absent Amino Acids W

Common Amino Acids L

Mass 34979.44

PI 5.73

Basic Residues 48

Acidic Residues 47

Hydrophobic Residues 131

Net Charge -5

Boman Index 81.29

Hydrophobicity -0.286

Aliphatic Index 88.34

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 21110

Absorbance 280nm 60.35

Polar Residues 64

number

22

A

18

R

10

N

21

D

5

C

26

E

6

Q

18

G

6

H

21

I

31

L

24

K

14

M

13

F

13

P

17

S

12

T

0

W

14

Y

16

V

Amino Acid Distribution

A: 22 R: 18 N: 10 D: 21 C: 5 E: 26 Q: 6 G: 18 H: 6 I: 21 L: 31 K: 24 M: 14 F: 13 P: 13 S: 17 T: 12 W: 0 Y: 14 V: 16

Length

307

Formula

C1558H2477N413O461S19

Mass

34979.44

PI

5.73

Net Charge

-5

Boman Index

81.29

Hydrophobicity

-0.286

Evidence 1 Activity

Source & Reference

Database Source NA