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Peptide record

TPDB72593

Neurotoxin standard
108 amino acids
Basic Information
3D PDB MODEL
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TPDB72593
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 108-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKTLLLTLVVVTIVCLDLAYTRKCYKTHPYKSEPCASGENLCYTKTWCDFRCSQLGKAVELGCAATCPTTKPYEEVTCCSTDDCNRFPNWERPRPRPRGLLSSIMDHP
Physicochemical Analysis
C533H844N146O158S13
T
12242.23
7.90
16
11
35
+3
20.21
-0.308
67.69
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
19075
155.81
38
Residue Composition
number
5
A
7
R
3
N
5
D
11
C
6
E
1
Q
4
G
2
H
2
I
11
L
7
K
2
M
2
F
9
P
6
S
12
T
2
W
5
Y
6
V
Amino Acid Distribution
A: 5 R: 7 N: 3 D: 5 C: 11 E: 6 Q: 1 G: 4 H: 2 I: 2 L: 11 K: 7 M: 2 F: 2 P: 9 S: 6 T: 12 W: 2 Y: 5 V: 6
Chemical Descriptors
108
C533H844N146O158S13
12242.23
7.90
+3
20.21
-0.308
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission. {ECO:0000250|UniProtKB:P60615}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Drysdalia coronoides (White-lipped snake) (Hoplocephalus coronoides)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission..
Long neurotoxin 13 (LNTX-13)
snake
Three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily
Long neurotoxin 13 (LNTX-13)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake