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Peptide record

TPDB72583

Neurotoxin standard
98 amino acids
Basic Information
3D PDB MODEL
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TPDB72583
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 98-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MMKLVLFGIIVILFSMIGSIHGSDPPGNYPLNTYGNKYACTILGENDFCQKICKVHGVQYGYCFNSRCWCEYLEEKDVNIWDAVKRHCKNTILYPKGK
Physicochemical Analysis
C509H778N130O138S10
GIK
11247.16
8.17
14
8
40
+3
9.54
-0.093
83.47
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
21805
193.87
30
Residue Composition
number
2
A
2
R
7
N
4
D
7
C
4
E
2
Q
9
G
3
H
9
I
7
L
9
K
3
M
4
F
4
P
4
S
3
T
2
W
7
Y
6
V
Amino Acid Distribution
A: 2 R: 2 N: 7 D: 4 C: 7 E: 4 Q: 2 G: 9 H: 3 I: 9 L: 7 K: 9 M: 3 F: 4 P: 4 S: 4 T: 3 W: 2 Y: 7 V: 6
Chemical Descriptors
98
C509H778N130O138S10
11247.16
8.17
+3
9.54
-0.093
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: The heterodimer non-edited LVP1 induces lipolysis in rat adipocytes. Induction of lipolysis by LVP1 appears to be mediated through the beta-2 adrenergic receptor pathway (ADRB2) (By similarity). {ECO:0000250|UniProtKB:P84810}. FUNCTION: The edited BmKBTx-like, similar to beta-toxins, may modulate voltage-gated sodium channels (Nav) and may block voltage-gated potassium channels (Kv). {ECO:0000250|UniProtKB:P84810}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus israelis (Israeli scorpion) (Buthus occitanus israelis)
Neurotoxin G-protein coupled receptor impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
The heterodimer non-edited LVP1 induces lipolysis in rat adipocytes. Induction of lipolysis by LVP1 appears to be mediated through the beta-2 adrenergic receptor pathway (ADRB2) (By similarity).. FUNCTION: The edited BmKBTx-like, similar to beta-toxins, may modulate voltage-gated sodium channels (Nav) and may block voltage-gated potassium channels (Kv)..
Lipolysis-activating peptide 1-alpha chain (BoiLVP1-alpha) (LVP1-alpha) (Putative beta-like toxin Tx458) (BoiTx458) (Putative beta-like toxin Tx651) (BoiTx651) (Putative beta-like toxin Tx764) (BoiTx764) (Putative beta-like toxin Tx814) (BoiTx814) [Cleaved into: Neurotoxin BmKBTx-like (Putative excitatory toxin Tx135) (BoiTx135)]
scorpion
Long (3 C-C) scorpion toxin superfamily
Evidence at transcript level
Amidation Disulfide bond G-protein coupled receptor impairing toxin Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin RNA editing Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000250|UniProtKB:P84810}.
Additional Detail Fields 7 fields
Amidation Disulfide bond G-protein coupled receptor impairing toxin Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin RNA editing Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin G-protein coupled receptor impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Long (3 C-C) scorpion toxin superfamily
Lipolysis-activating peptide 1-alpha chain (BoiLVP1-alpha) (LVP1-alpha) (Putative beta-like toxin Tx458) (BoiTx458) (Putative beta-like toxin Tx651) (BoiTx651) (Putative beta-like toxin Tx764) (BoiTx764) (Putative beta-like toxin Tx814) (BoiTx814) [Cleaved into: Neurotoxin BmKBTx-like (Putative excitatory toxin Tx135) (BoiTx135)]
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000250|UniProtKB:P84810}.
scorpion