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Peptide record

TPDB72578

Neurotoxin standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB72578
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 50-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MISMLRCTFFFVSVILITSYFVTPTMSIKCNRKRHVIKPHICRKICGKNG
Physicochemical Analysis
C262H431N73O62S7
ADEQW
I
5820.18
10.74
11
0
21
+9
2.83
0.412
93.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
29.90
15
Residue Composition
number
0
A
4
R
2
N
0
D
4
C
0
E
0
Q
2
G
2
H
7
I
2
L
5
K
3
M
4
F
2
P
4
S
4
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 4 N: 2 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 2 I: 7 L: 2 K: 5 M: 3 F: 4 P: 2 S: 4 T: 4 W: 0 Y: 1 V: 4
Chemical Descriptors
50
C262H431N73O62S7
5820.18
10.74
+9
2.83
0.412
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent anti-inflammatory agent. At low concentrations, mediates the degranulation of mast cells thus evoking an inflammatory response. Also acts as a neurotoxin capable of blocking a class of voltage-gated potassium channels.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Apis cerana cerana (Oriental honeybee)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Potent anti-inflammatory agent. At low concentrations, mediates the degranulation of mast cells thus evoking an inflammatory response.
Mast cell degranulating peptide
insect
Evidence at transcript level
Amidation Disulfide bond Formylation Ion channel impairing toxin Mast cell degranulation Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 6 fields
Amidation Disulfide bond Formylation Ion channel impairing toxin Mast cell degranulation Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at transcript level
Mast cell degranulating peptide
TISSUE SPECIFICITY: Expressed by the venom gland.
insect