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Peptide record

TPDB72575

Neurotoxin standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB72575
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 11-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
ESNFKIGMAIR
Physicochemical Analysis
C55H92N16O16S1
DCQHLPTWYV
I
1265.49
10.09
2
1
5
+1
2.23
-0.100
80.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
1
E
0
Q
1
G
0
H
2
I
0
L
1
K
1
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 1 M: 1 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C55H92N16O16S1
1265.49
10.09
+1
2.23
-0.100
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: This insecticidal neurotoxin targets two types of channels/receptors. It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN). It inhibits glutamate uptake from rat brain synaptosomes, and blocks GRIN in hippocampal slices. It also acts on sodium channels of both insects and mammals. On sodium channel insects, it strongly slows down channel inactivation (EC(50)=212.5 nM) and causes an increase (105%) in peak amplitude (at 1 uM) of B.germanica sodium channel (Nav), whereas it inhibits all mammalien sodium channels tested with the following order of potency: Nav1.3/SCN3A (IC(50)=1.5 uM) > Nav1.6/SCN8A > Nav1.5/SCN5A > Nav1.4/SCN4A >= Nav1.2/SCN2A. In vivo, it is highly toxic to house fly (Musca domestica), cockroach (Periplaneta americana), and cricket (Acheta domesticus). In different rat pain models (induced by PGE2, carrageenan or glutamate), it shows antinociceptive effect that may be related to an inhibitory activity on the glutamatergic system. {ECO:0000250|UniProtKB:P59367}.

Target

voltage-gated sodium channel (Nav) glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria boliviensis (Brazilian wandering spider)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
This insecticidal neurotoxin targets two types of channels/receptors. It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN).
GAMMA-ctenitoxin-Pb1a (GAMMA-CNTX-Pb1a) (Ctenitoxin-Pb53)
spider
Neurotoxin 03 (Tx2) family, 05 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26264023}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 05 subfamily
GAMMA-ctenitoxin-Pb1a (GAMMA-CNTX-Pb1a) (Ctenitoxin-Pb53)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26264023}.
spider