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Peptide record

TPDB72574

Neurotoxin standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB72574
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 11-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
CDLAMGNCICK
Physicochemical Analysis
C45H79N13O15S4
REQHFPSTWYV
C
1170.44
5.86
1
1
4
-0
0.66
0.745
80.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
10.68
4
Residue Composition
number
1
A
0
R
1
N
1
D
3
C
0
E
0
Q
1
G
0
H
1
I
1
L
1
K
1
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 3 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 1 M: 1 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C45H79N13O15S4
1170.44
5.86
-0
0.66
0.745
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits high-voltage activated calcium channels. Shifts the voltage-dependence for activation towards hyperpolarized membrane potentials for L- (Cav1), P/Q- (Cav2.1/CACNA1A) and R-type (Cav2.3/CACNA1E) calcium currents. In vivo, causes immediate agitation and clockwise gyration, followed by the gradual development of general flaccid paralysis when injected intracerebroventricular into mice at dose levels of 5 ug per mouse. {ECO:0000250|UniProtKB:P83911}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria boliviensis (Brazilian wandering spider)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits high-voltage activated calcium channels. Shifts the voltage-dependence for activation towards hyperpolarized membrane potentials for L- (Cav1), P/Q- (Cav2.1/CACNA1A) and R-type (Cav2.3/CACNA1E) calcium currents.
Omega-ctenitoxin-Pb1a (Omega-CNTX-Pb1a) (Omega-ctenitoxin-Pb48)
spider
Neurotoxin 02 (plectoxin) family
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26264023}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family
Omega-ctenitoxin-Pb1a (Omega-CNTX-Pb1a) (Omega-ctenitoxin-Pb48)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26264023}.
spider