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Peptide record

TPDB72568

Neurotoxin standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB72568
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 15-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
EKSCITWRNSCVHND
Physicochemical Analysis
C73H114N24O25S2
AQGLMFPY
NCS
1791.97
7.00
3
2
3
+0
4.68
-1.007
45.33
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
5625
313.90
7
Residue Composition
number
0
A
1
R
2
N
1
D
2
C
1
E
0
Q
0
G
1
H
1
I
0
L
1
K
0
M
0
F
0
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 1 C: 2 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
15
C73H114N24O25S2
1791.97
7.00
+0
4.68
-1.007
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Modulates Cav2.1/CACNA1A voltage-gated calcium channels (P/Q-type currents) in rat cerebellar Purkinje cells and hippocampal CA1-CA3 neurons. At saturating concentrations (>10 nM) decelerates activation kinetics and slightly increases peak amplitude without affecting deactivation kinetics (By similarity). In vivo, does not cause death when intravenously injected into mice (PubMed:36588719). In rat models, through its activity on Cav2.1/CACNA1A, has an ameliorative effect on memory defects provoked by hyperstimulation of N-methyl-D-aspartate receptors (NMDARs) in the hippocampus (PubMed:36588719). {ECO:0000250|UniProtKB:P85079, ECO:0000269|PubMed:36588719}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lycosa praegrandis (Wolf spider)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Modulates Cav2.1/CACNA1A voltage-gated calcium channels (P/Q-type currents) in rat cerebellar Purkinje cells and hippocampal CA1-CA3 neurons. At saturating concentrations (>10 nM) decelerates activation kinetics and slightly increases peak amplitude without affecting deactivation kinetics (By similarity).
Omega-lycotoxin-Lp1a (Omega-LCTX-Lp1a) (Omega-lycotoxin Gsp(267)1e) (OLG1e)
spider
Neurotoxin omega-lctx family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:36588719}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin omega-lctx family
Omega-lycotoxin-Lp1a (Omega-LCTX-Lp1a) (Omega-lycotoxin Gsp(267)1e) (OLG1e)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:36588719}.
spider