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Peptide record

TPDB72564

Neurotoxin standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB72564
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 36-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
DGANAEATDNKPGVFERDEKKCCWNRACTRLVPCSK
Physicochemical Analysis
C166H267N53O55S4
QHIMY
ACK
4013.51
7.84
7
6
9
+1
13.69
-0.986
38.06
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
5750
143.27
10
Residue Composition
number
4
A
3
R
3
N
3
D
4
C
3
E
0
Q
2
G
0
H
0
I
1
L
4
K
0
M
1
F
2
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 3 N: 3 D: 3 C: 4 E: 3 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 4 M: 0 F: 1 P: 2 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
36
C166H267N53O55S4
4013.51
7.84
+1
13.69
-0.986
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus bullatus (Bubble cone)
Neurotoxin Ion channel impairing toxin
Conotoxin Bu21
cone snail
Conotoxin A superfamily
Evidence at transcript level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:21266071}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Conotoxin A superfamily
Conotoxin Bu21
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:21266071}.
cone snail