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Peptide record

TPDB72561

Neurotoxin standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB72561
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 44-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
KKVYSFLKLKGCLPRNRFCNALSGPRCCSGLRCKELSIWASKCL
Physicochemical Analysis
C219H363N65O55S6
DQHMT
L
4979.05
10.13
10
1
15
+9
2.63
-0.068
82.05
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
7365
147.92
14
Residue Composition
number
2
A
4
R
2
N
0
D
6
C
1
E
0
Q
3
G
0
H
1
I
7
L
6
K
0
M
2
F
2
P
5
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 7 K: 6 M: 0 F: 2 P: 2 S: 5 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
44
C219H363N65O55S6
4979.05
10.13
+9
2.63
-0.068
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insect active toxin causing rapid but reversible paralysis in crickets. No activity shown in mammals. Does not show effect on mammalian voltage-gated calcium channels (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelena orientalis (Funnel-web spider)
Neurotoxin
Insect active toxin causing rapid but reversible paralysis in crickets. No activity shown in mammals.
U2-agatoxin-Ao1s (U2-AGTX-Ao1s) (Agel_18)
spider
Neurotoxin 01 (U2-agtx) family
Evidence at transcript level
Disulfide bond Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Knottin Neurotoxin Secreted Toxin
Neurotoxin
Evidence at transcript level
Neurotoxin 01 (U2-agtx) family
U2-agatoxin-Ao1s (U2-AGTX-Ao1s) (Agel_18)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider