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Peptide record

TPDB72560

Neurotoxin standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB72560
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 40-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
VVLGPASDGRNAAANNKASDLIRQICCGYGDCGFVPNVCV
Physicochemical Analysis
C171H276N52O55S4
EHMTW
AGV
4068.63
6.03
3
3
16
-0
4.50
0.260
87.75
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1740
42.77
12
Residue Composition
number
5
A
2
R
4
N
3
D
4
C
0
E
1
Q
5
G
0
H
2
I
2
L
1
K
0
M
1
F
2
P
2
S
0
T
0
W
1
Y
5
V
Amino Acid Distribution
A: 5 R: 2 N: 4 D: 3 C: 4 E: 0 Q: 1 G: 5 H: 0 I: 2 L: 2 K: 1 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 1 V: 5
Chemical Descriptors
40
C171H276N52O55S4
4068.63
6.03
-0
4.50
0.260
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus leopardus (Leopard cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like Lp1.6b
cone snail
Conotoxin A superfamily
Evidence at transcript level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17400270}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at transcript level
Conotoxin A superfamily
Alpha-conotoxin-like Lp1.6b
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17400270}.
cone snail