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Peptide record

TPDB72558

Neurotoxin standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB72558
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 37-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
KSTSCMEAGSYCGSTTRICCGYCAYSASKNVCDYPSN
Physicochemical Analysis
C158H244N44O58S7
QHLFW
S
3912.36
7.62
3
2
10
+1
2.51
-0.297
26.49
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6335
161.92
22
Residue Composition
number
3
A
1
R
2
N
1
D
6
C
1
E
0
Q
3
G
0
H
1
I
0
L
2
K
1
M
0
F
1
P
7
S
3
T
0
W
4
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 2 M: 1 F: 0 P: 1 S: 7 T: 3 W: 0 Y: 4 V: 1
Chemical Descriptors
37
C158H244N44O58S7
3912.36
7.62
+1
2.51
-0.297
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-, P- and Q-type calcium channels (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus striatus (Striated cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-, P- and Q-type calcium channels (By similarity)..
Omega-conotoxin-like S6.7
cone snail
Conotoxin O1 superfamily
Evidence at transcript level
Amidation Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at transcript level
Conotoxin O1 superfamily
Omega-conotoxin-like S6.7
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail