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Peptide record

TPDB72557

Neurotoxin standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB72557
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 41-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
PCFCGKTVGIYWFALYSCPGGYGYTGHCGHFMGVCCYPANP
Physicochemical Analysis
C203H276N48O51S7
RDEQ
G
4429.14
7.64
3
0
16
+1
-7.06
0.307
38.05
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
13325
300.85
15
Residue Composition
number
2
A
0
R
1
N
0
D
6
C
0
E
0
Q
8
G
2
H
1
I
1
L
1
K
1
M
3
F
4
P
1
S
2
T
1
W
5
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 6 E: 0 Q: 0 G: 8 H: 2 I: 1 L: 1 K: 1 M: 1 F: 3 P: 4 S: 1 T: 2 W: 1 Y: 5 V: 2
Chemical Descriptors
41
C203H276N48O51S7
4429.14
7.64
+1
-7.06
0.307
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potently and selectively inhibits voltage-gated potassium channels Kv11/KCNH/ERG. Acts as a gating-modifier toxin that shifts the voltage-dependence of ERG activation in the positive direction and suppresses its current amplitudes elicited by strong depolarizing pulses that maximally activate the channels. {ECO:0000250|UniProtKB:P61541}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma granuliferum (Red warty sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potently and selectively inhibits voltage-gated potassium channels Kv11/KCNH/ERG. Acts as a gating-modifier toxin that shifts the voltage-dependence of ERG activation in the positive direction and suppresses its current amplitudes elicited by strong depolarizing pulses that maximally activate the channels..
U-AITX-Bg1a
sea anemone
Sea anemone type 3 (BDS) potassium channel toxin family
Evidence at transcript level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at transcript level
Sea anemone type 3 (BDS) potassium channel toxin family
U-AITX-Bg1a
sea anemone