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Peptide record

TPDB72547

Neurotoxin standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB72547
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 42-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
YKQCHKKGGHCFPKEKICIPPSSDFGKMDCRWRWKCCKKGSG
Physicochemical Analysis
C214H332N64O54S7
ANLTV
K
4889.81
9.75
13
3
8
+8
10.11
-1.079
18.57
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12865
263.10
11
Residue Composition
number
0
A
2
R
0
N
2
D
6
C
1
E
1
Q
5
G
2
H
2
I
0
L
9
K
1
M
2
F
3
P
3
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 2 C: 6 E: 1 Q: 1 G: 5 H: 2 I: 2 L: 0 K: 9 M: 1 F: 2 P: 3 S: 3 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
42
C214H332N64O54S7
4889.81
9.75
+8
10.11
-1.079
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor, it induces severe muscle necrosis by a non-enzymatic mechanism and exhibits antimicrobial activities (By similarity). It also elicits a short-lasting hyperextension of the hind limb (Ref.1). It does not cause observable tissue damage (whereas the whole venom causes severe myonecrosis accompanied by edema and hemorrhage) (Ref.1). {ECO:0000250|UniProtKB:Q9PWF3, ECO:0000269|Ref.1}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus durissus ruruima (South American rattlesnake) (Mt. Roraima rattlesnake)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor, it induces severe muscle necrosis by a non-enzymatic mechanism and exhibits antimicrobial activities (By similarity).
Crotamine Ile-19 (CRO_Ile-19)
snake
Crotamine-myotoxin family
Evidence at protein level
3D-structure Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
3D-structure Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Crotamine-myotoxin family
Crotamine Ile-19 (CRO_Ile-19)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
snake