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Peptide record

TPDB72545

Neurotoxin standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB72545
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 38-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
SNGRNAAAGDKPSYWITLAITDCCANPVCNGKHCQGRR
Physicochemical Analysis
C167H267N57O53S4
EMF
A
4049.55
8.71
6
2
11
+3
5.86
-0.605
51.58
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
7240
178.79
14
Residue Composition
number
5
A
3
R
4
N
2
D
4
C
0
E
1
Q
4
G
1
H
2
I
1
L
2
K
0
M
0
F
2
P
2
S
2
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 5 R: 3 N: 4 D: 2 C: 4 E: 0 Q: 1 G: 4 H: 1 I: 2 L: 1 K: 2 M: 0 F: 0 P: 2 S: 2 T: 2 W: 1 Y: 1 V: 1
Chemical Descriptors
38
C167H267N57O53S4
4049.55
8.71
+3
5.86
-0.605
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This synthetic peptide inhibits rat alpha-6/alpha-3-beta-4 nAChR (IC(50)=3.3 uM). {ECO:0000269|PubMed:36682014}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus lividus (Livid cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This synthetic peptide inhibits rat alpha-6/alpha-3-beta-4 nAChR (IC(50)=3.3 uM)..
Alpha-conotoxin LvIC
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:36682014}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin LvIC
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:36682014}.
cone snail