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Peptide record

TPDB72544

Neurotoxin standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB72544
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 43-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
CLCNSDGPSVRGNTLSGILWLAGCPSGWHNCKKHKPTIGWCCK
Physicochemical Analysis
C200H312N60O55S6
EQMFY
CG
4629.41
8.59
7
1
11
+4
1.44
-0.228
63.49
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
16875
364.52
15
Residue Composition
number
1
A
1
R
3
N
1
D
6
C
0
E
0
Q
6
G
2
H
2
I
4
L
4
K
0
M
0
F
3
P
4
S
2
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 3 D: 1 C: 6 E: 0 Q: 0 G: 6 H: 2 I: 2 L: 4 K: 4 M: 0 F: 0 P: 3 S: 4 T: 2 W: 3 Y: 0 V: 1
Chemical Descriptors
43
C200H312N60O55S6
4629.41
8.59
+4
1.44
-0.228
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (PubMed:31330191). Thus it strongly stimulates mammalian cardiac muscle contraction (By similarity). {ECO:0000250|UniProtKB:P01529, ECO:0000305|PubMed:31330191}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma capense (Knobbly sea anemone) (Actinia capensis)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (PubMed:31330191). Thus it strongly stimulates mammalian cardiac muscle contraction (By similarity)..
Delta-actitoxin-Bca1a (Delta-AITX-Bca1a)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Bca1a (Delta-AITX-Bca1a)
sea anemone