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Peptide record

TPDB72543

Neurotoxin standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB72543
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 36-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
ECRWFWGGCNNDADCCKHLECKRKWPHICLWDGTFT
Physicochemical Analysis
C192H273N55O51S6
QMSYV
C
4359.98
6.91
7
5
10
-0
3.14
-0.692
35.28
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
22375
513.19
10
Residue Composition
number
1
A
2
R
2
N
3
D
6
C
2
E
0
Q
3
G
2
H
1
I
2
L
3
K
0
M
2
F
1
P
0
S
2
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 3 C: 6 E: 2 Q: 0 G: 3 H: 2 I: 1 L: 2 K: 3 M: 0 F: 2 P: 1 S: 0 T: 2 W: 4 Y: 0 V: 0
Chemical Descriptors
36
C192H273N55O51S6
4359.98
6.91
-0
3.14
-0.692
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin that targets both voltage-gated sodium and calcium channels, with described activities on human Nav1.7/SCN9A (IC(50)=5.5-7 nM), hNav1.6/SCN10A (IC(50)=9.9 nM), hNav1.4/SCN4A (IC(50)=62.9 nM), hCav3.2/CACNA1H (IC(50)=955.4 nM or 63.5% inhibition at 10 uM), hCav3.1/CACNA1G (95.1% inhibition at 10 uM), hCav3.3/CACNA1I (90.8% inhibition at 10 uM). Acts on Cav3 currents mainly by inducing a strong depolarizing shift in the current-voltage curve. {ECO:0000269|PubMed:36912793}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pterinochilus murinus (Mombasa golden starburst baboon spider)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that targets both voltage-gated sodium and calcium channels, with described activities on human Nav1.7/SCN9A (IC(50)=5.5-7 nM), hNav1.6/SCN10A (IC(50)=9.9 nM), hNav1.4/SCN4A (IC(50)=62.9 nM), hCav3.2/CACNA1H (IC(50)=955.4 nM or 63.5% inhibition at 10 uM), hCav3.1/CACNA1G (95.1% inhibition at 10 uM), hCav3.3/CACNA1I (90.8% inhibition at 10 uM). Acts on Cav3 currents mainly by inducing a strong depolarizing shift in the current-voltage curve..
Mu/omega-theraphotoxin-Pmu1a (Mu/omega-TRTX-Pmu1a)
spider
Neurotoxin 10 (Hwtx-1) family
Evidence at protein level
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:36912793}.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family
Mu/omega-theraphotoxin-Pmu1a (Mu/omega-TRTX-Pmu1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:36912793}.
spider