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Peptide record

TPDB72542

Neurotoxin standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB72542
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 43-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
AAPCSCPGKPGRGDLWIFRGTCPGGYGYTSNCYKWPNICCYPH
Physicochemical Analysis
C209H299N57O56S6
EQMV
G
4698.38
8.30
5
1
12
+3
-1.61
-0.435
31.86
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
17335
368.96
16
Residue Composition
number
2
A
2
R
2
N
1
D
6
C
0
E
0
Q
7
G
1
H
2
I
1
L
2
K
0
M
1
F
6
P
2
S
2
T
2
W
4
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 1 C: 6 E: 0 Q: 0 G: 7 H: 1 I: 2 L: 1 K: 2 M: 0 F: 1 P: 6 S: 2 T: 2 W: 2 Y: 4 V: 0
Chemical Descriptors
43
C209H299N57O56S6
4698.38
8.30
+3
-1.61
-0.435
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv3 voltage-gated potassium channels (By similarity). Reduces blood pressure (By similarity). {ECO:0000250|UniProtKB:P11494}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia viridis (Snakelocks anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Kv3 voltage-gated potassium channels (By similarity). Reduces blood pressure (By similarity)..
Kappa-actitoxin-Avd4p (Kappa-AITX-Avd4p) (Blood depressing substance 16) (BDS-16)
sea anemone
Sea anemone type 3 (BDS) potassium channel toxin family
Evidence at protein level
Direct protein sequencing Disulfide bond Hypotensive agent Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Hypotensive agent Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 3 (BDS) potassium channel toxin family
Kappa-actitoxin-Avd4p (Kappa-AITX-Avd4p) (Blood depressing substance 16) (BDS-16)
sea anemone