Back to search

Peptide record

TPDB72541

Neurotoxin standard
41 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72541
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 41-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
SDGRNEAANDEASDVIELALKGCCSNPVCHLEHPNACGRRR
Physicochemical Analysis
C176H288N62O63S4
QMFTWY
A
4408.84
5.36
7
7
11
-2
17.26
-0.739
64.39
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
250
5.67
11
Residue Composition
number
5
A
4
R
4
N
3
D
4
C
4
E
0
Q
3
G
2
H
1
I
3
L
1
K
0
M
0
F
2
P
3
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 4 N: 4 D: 3 C: 4 E: 4 Q: 0 G: 3 H: 2 I: 1 L: 3 K: 1 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
41
C176H288N62O63S4
4408.84
5.36
-2
17.26
-0.739
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks rat neuronal nAChR alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=128.9 nM) and alpha-7/CHRNA7 (IC(50)=1511 nM) (PubMed:29857567). In vivo, intramuscular injection into zebrafish does not produce any effect on the locomotion of zebrafish (PubMed:29857567). {ECO:0000269|PubMed:29857567}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus catus (Cat cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks rat neuronal nAChR alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=128.9 nM) and alpha-7/CHRNA7 (IC(50)=1511 nM) (PubMed:29857567).
Alpha-conotoxin CIB (C1.2)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:29857567}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin CIB (C1.2)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:29857567}.
cone snail