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Peptide record

TPDB72538

Neurotoxin standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB72538
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 47-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
CLSVCSMEYWPVCGSDGKTYPNECHLTSEACMSNTDITVAHVGKCDQ
Physicochemical Analysis
C212H327N57O74S8
RF
C
5114.75
4.36
4
6
14
-4
10.09
-0.194
53.83
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
8855
173.13
20
Residue Composition
number
2
A
0
R
2
N
3
D
6
C
3
E
1
Q
3
G
2
H
1
I
2
L
2
K
2
M
0
F
2
P
5
S
4
T
1
W
2
Y
4
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 3 C: 6 E: 3 Q: 1 G: 3 H: 2 I: 1 L: 2 K: 2 M: 2 F: 0 P: 2 S: 5 T: 4 W: 1 Y: 2 V: 4
Chemical Descriptors
47
C212H327N57O74S8
5114.75
4.36
-4
10.09
-0.194
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as a neurotoxin by inhibiting an ion channel (By similarity). May also act as a serine protease inhibitor, since it possess the kazal serine protease inhibitor signature. {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Iotyrris cingulifera (Sea snail) (Pleurotoma cingulifera)
Neurotoxin Ion channel impairing toxin
Acts as a neurotoxin by inhibiting an ion channel (By similarity). May also act as a serine protease inhibitor, since it possess the kazal serine protease inhibitor signature..
Turripeptide Ici9.1 (Turripeptide OL11-like)
other
Conopeptide P-like superfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Protease inhibitor Secreted Serine protease inhibitor Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Protease inhibitor Secreted Serine protease inhibitor Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Conopeptide P-like superfamily
Turripeptide Ici9.1 (Turripeptide OL11-like)
TISSUE SPECIFICITY: Expressed by the venom duct.
other