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Peptide record

TPDB72536

Neurotoxin standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB72536
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 37-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
TVSDPPARPAVFHSREELMNYVRELNRYFAIVGRPRF
Physicochemical Analysis
C198H305N59O53S1
CQKW
R
4392.02
10.23
7
4
16
+2
9.00
-0.495
71.08
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
2980
67.85
7
Residue Composition
number
3
A
6
R
2
N
1
D
0
C
3
E
0
Q
1
G
1
H
1
I
2
L
0
K
1
M
3
F
4
P
2
S
1
T
0
W
2
Y
4
V
Amino Acid Distribution
A: 3 R: 6 N: 2 D: 1 C: 0 E: 3 Q: 0 G: 1 H: 1 I: 1 L: 2 K: 0 M: 1 F: 3 P: 4 S: 2 T: 1 W: 0 Y: 2 V: 4
Chemical Descriptors
37
C198H305N59O53S1
4392.02
10.23
+2
9.00
-0.495
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Causes hyperactivity such as jumping, rapid circling and tail flicking, when intraventricularly injected into mice brain. {ECO:0000269|PubMed:20705590}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus betulinus (Beech cone)
Neurotoxin
Causes hyperactivity such as jumping, rapid circling and tail flicking, when intraventricularly injected into mice brain..
Neuropeptide Y1-like conopeptide (Cono-NPY1) (NPY1-like conopeptide)
cone snail
NPY family
Evidence at protein level
Amidation Direct protein sequencing Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20705590}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
NPY family
Neuropeptide Y1-like conopeptide (Cono-NPY1) (NPY1-like conopeptide)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20705590}.
cone snail