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Peptide record

TPDB72535

Neurotoxin standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB72535
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 47-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
GVPCRCDSDGPSVHGNTLSGTVWVGSCASGWHKCNTEHNIFHECCKE
Physicochemical Analysis
C210H315N65O69S6
QMY
CG
5046.57
6.02
7
5
10
-2
11.41
-0.466
43.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11375
225.40
17
Residue Composition
number
1
A
1
R
3
N
2
D
6
C
3
E
0
Q
6
G
4
H
1
I
1
L
2
K
0
M
1
F
2
P
5
S
3
T
2
W
0
Y
4
V
Amino Acid Distribution
A: 1 R: 1 N: 3 D: 2 C: 6 E: 3 Q: 0 G: 6 H: 4 I: 1 L: 1 K: 2 M: 0 F: 1 P: 2 S: 5 T: 3 W: 2 Y: 0 V: 4
Chemical Descriptors
47
C210H315N65O69S6
5046.57
6.02
-2
11.41
-0.466
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation, thereby blocking neuronal transmission (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Condylactis gigantea (Giant Caribbean anemone) (Condylactis passiflora)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation, thereby blocking neuronal transmission (By similarity)..
Delta-actitoxin-Cgg1b (Delta-AITX-Cgg1b) (Cp-1) (Cp I) (CpI) (Delta-actitoxin-Cps1a) (Delta-AITX-Cps1a)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Cgg1b (Delta-AITX-Cgg1b) (Cp-1) (Cp I) (CpI) (Delta-actitoxin-Cps1a) (Delta-AITX-Cps1a)
sea anemone