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Peptide record

TPDB72532

Neurotoxin standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB72532
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 38-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
TTINVKCSLPQQCLRPCKDRFGQHAGGKCINGKCKCYP
Physicochemical Analysis
C177H292N56O50S6
EMW
C
4196.97
9.24
8
1
8
+6
7.79
-0.584
51.32
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
44.44
15
Residue Composition
number
1
A
2
R
2
N
1
D
6
C
0
E
3
Q
4
G
1
H
2
I
2
L
5
K
0
M
1
F
3
P
1
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 1 C: 6 E: 0 Q: 3 G: 4 H: 1 I: 2 L: 2 K: 5 M: 0 F: 1 P: 3 S: 1 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
38
C177H292N56O50S6
4196.97
9.24
+6
7.79
-0.584
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits human voltage-gated potassium (Kv) channels Kv1.2/KCNA2 (Kd=0.585 nM) and Kv1.3/KCNA3 (Kd=160 nM). {ECO:0000269|PubMed:37624263}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides bonito (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits human voltage-gated potassium (Kv) channels Kv1.2/KCNA2 (Kd=0.585 nM) and Kv1.3/KCNA3 (Kd=160 nM)..
Potassium channel toxin alpha-KTx 2.21 (CboK6)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.21 (CboK6)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
scorpion