Back to search

Peptide record

TPDB72531

Neurotoxin standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72531
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 32-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
TVCVYRTCDKDCKRRGYRSGKCINNACKCYPY
Physicochemical Analysis
C157H252N50O46S6
EQHLMFW
C
3768.40
9.14
8
2
8
+6
5.84
-0.866
33.44
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
6335
168.11
15
Residue Composition
number
1
A
4
R
2
N
2
D
6
C
0
E
0
Q
2
G
0
H
1
I
0
L
4
K
0
M
0
F
1
P
1
S
2
T
0
W
4
Y
2
V
Amino Acid Distribution
A: 1 R: 4 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 4 M: 0 F: 0 P: 1 S: 1 T: 2 W: 0 Y: 4 V: 2
Chemical Descriptors
32
C157H252N50O46S6
3768.40
9.14
+6
5.84
-0.866
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks human voltage-gated potassium (Kv) channels Kv1.2/KCNA2 (Kd=0.76 nM) and Kv1.3/KCNA3 (Kd=171 nM). {ECO:0000269|PubMed:37624263}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides bonito (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks human voltage-gated potassium (Kv) channels Kv1.2/KCNA2 (Kd=0.76 nM) and Kv1.3/KCNA3 (Kd=171 nM)..
Potassium channel toxin alpha-KTx 10.6 (CboK2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Potassium channel toxin alpha-KTx 10.6 (CboK2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
scorpion