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Peptide record

TPDB72530

Neurotoxin standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB72530
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 33-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
NVACVHRTCDSNCKRNGYKSGKCINRKCNCYPH
Physicochemical Analysis
C152H247N55O46S6
EQLMFW
C
3773.33
9.21
9
1
6
+6
8.85
-1.033
32.42
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
3355
88.91
16
Residue Composition
number
1
A
3
R
5
N
1
D
6
C
0
E
0
Q
2
G
2
H
1
I
0
L
4
K
0
M
0
F
1
P
2
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 5 D: 1 C: 6 E: 0 Q: 0 G: 2 H: 2 I: 1 L: 0 K: 4 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
33
C152H247N55O46S6
3773.33
9.21
+6
8.85
-1.033
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin with unknown function. {ECO:0000305|PubMed:37624263}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides bonito (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Toxin with unknown function..
Potassium channel toxin alpha-KTx 10.5 (CboK1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Potassium channel toxin alpha-KTx 10.5 (CboK1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
scorpion