Back to search

Peptide record

TPDB72529

Neurotoxin standard
38 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72529
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 38-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
TNGVPGKCTKPGGCSTYCRDTTGTMGLCKNSKCYCNKY
Physicochemical Analysis
C165H267N49O55S7
AEQHIFW
CGT
4041.65
8.85
6
1
6
+5
5.33
-0.747
17.89
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
4845
119.88
20
Residue Composition
number
0
A
1
R
3
N
1
D
6
C
0
E
0
Q
6
G
0
H
0
I
1
L
5
K
1
M
0
F
2
P
2
S
6
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 3 D: 1 C: 6 E: 0 Q: 0 G: 6 H: 0 I: 0 L: 1 K: 5 M: 1 F: 0 P: 2 S: 2 T: 6 W: 0 Y: 3 V: 1
Chemical Descriptors
38
C165H267N49O55S7
4041.65
8.85
+5
5.33
-0.747
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: A probable toxin that has no activity on the tested mammalian voltage-gated potassium channels (when tested at 1 uM) and is not toxic to mice (PubMed:36364113). It resembles alpha toxins that block voltage-gated potassium channels (Probable). {ECO:0000269|PubMed:36364113, ECO:0000305}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
A probable toxin that has no activity on the tested mammalian voltage-gated potassium channels (when tested at 1 uM) and is not toxic to mice (PubMed:36364113). It resembles alpha toxins that block voltage-gated potassium channels (Probable)..
Toxin Bot33 (Potassium channel toxin alpha-KTx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:36364113}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family
Toxin Bot33 (Potassium channel toxin alpha-KTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:36364113}.
scorpion