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Peptide record

TPDB72527

Neurotoxin standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB72527
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 42-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
DRDSCVDKSRCAKYGYFQECTDCCKKYGHNGGTCMFFKCKCA
Physicochemical Analysis
C200H304N58O62S9
ILPW
C
4801.51
8.09
9
5
10
+3
8.41
-0.726
11.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
4970
103.51
17
Residue Composition
number
2
A
2
R
1
N
4
D
8
C
1
E
1
Q
4
G
1
H
0
I
0
L
6
K
1
M
3
F
0
P
2
S
2
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 4 C: 8 E: 1 Q: 1 G: 4 H: 1 I: 0 L: 0 K: 6 M: 1 F: 3 P: 0 S: 2 T: 2 W: 0 Y: 3 V: 1
Chemical Descriptors
42
C200H304N58O62S9
4801.51
8.09
+3
8.41
-0.726
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks human Kv11.1/KCNH2/ERG1 potassium channels (reversible, IC(50)=3.4 nM) (PubMed:34201318). At high toxin concentrations, block of Kv11.1/KCNH2/ERG1 macroscopic current is almost complete (PubMed:34201318). Does not accelerate the kinetics of the closing process and has no effect on the activation and inactivation kinetics of the Kv11.1/KCNH2/ERG1 channels (PubMed:34201318). {ECO:0000269|PubMed:34201318}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides margaritatus (Central American bark Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks human Kv11.1/KCNH2/ERG1 potassium channels (reversible, IC(50)=3.4 nM) (PubMed:34201318). At high toxin concentrations, block of Kv11.1/KCNH2/ERG1 macroscopic current is almost complete (PubMed:34201318).
Potassium channel toxin gamma-KTx 1.10 (CmERG1)
scorpion
Ergtoxin family, Gamma-KTx 1 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:34201318}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Ergtoxin family, Gamma-KTx 1 subfamily
Potassium channel toxin gamma-KTx 1.10 (CmERG1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:34201318}.
scorpion