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Peptide record

TPDB72523

Neurotoxin standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB72523
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 42-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
GTPCYCGKTIGIYWFGTKTCPSNRGYTGSCGYFLGICCYPVD
Physicochemical Analysis
C204H295N49O58S6
AEQHM
G
4554.24
8.01
3
1
13
+2
-4.84
0.055
44.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
13325
292.58
19
Residue Composition
number
0
A
1
R
1
N
1
D
6
C
0
E
0
Q
8
G
0
H
3
I
1
L
2
K
0
M
2
F
3
P
2
S
5
T
1
W
5
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 6 E: 0 Q: 0 G: 8 H: 0 I: 3 L: 1 K: 2 M: 0 F: 2 P: 3 S: 2 T: 5 W: 1 Y: 5 V: 1
Chemical Descriptors
42
C204H295N49O58S6
4554.24
8.01
+2
-4.84
0.055
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to voltage-gated sodium channels (Nav), and slows down the inactivation of mammalian Nav1.2/SCN2A, Nav1.3/SCN3A Nav1.4/SCN4A, Nav1.6/SCN8A, insect DmNav1 and BgNav1 channels, and arachnid VdNav1 channel (PubMed:22972919). This toxin acts by binding to site 3 of sodium channels. {ECO:0000269|PubMed:22972919}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to voltage-gated sodium channels (Nav), and slows down the inactivation of mammalian Nav1.2/SCN2A, Nav1.3/SCN3A Nav1.4/SCN4A, Nav1.6/SCN8A, insect DmNav1 and BgNav1 channels, and arachnid VdNav1 channel (PubMed:22972919). This toxin acts by binding to site 3 of sodium channels..
Delta-actitoxin-Ael2d (Delta-AITX-Ael2d) (Toxin APETx3)
sea anemone
Sea anemone type 3 (BDS) potassium channel toxin family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone type 3 (BDS) potassium channel toxin family
Delta-actitoxin-Ael2d (Delta-AITX-Ael2d) (Toxin APETx3)
sea anemone