Back to search

Peptide record

TPDB72521

Neurotoxin standard
48 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72521
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 48-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MRLFLIFTFIVASLASVYGCIPAANPCRGNAKCCGNYVCKNGRCLPRS
Physicochemical Analysis
C228H366N66O59S7
DEQHW
C
5200.24
9.25
6
0
21
+6
-1.93
0.494
85.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
64.52
16
Residue Composition
number
5
A
4
R
4
N
0
D
6
C
0
E
0
Q
4
G
0
H
3
I
4
L
2
K
1
M
3
F
3
P
3
S
1
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 5 R: 4 N: 4 D: 0 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 4 K: 2 M: 1 F: 3 P: 3 S: 3 T: 1 W: 0 Y: 2 V: 3
Chemical Descriptors
48
C228H366N66O59S7
5200.24
9.25
+6
-1.93
0.494
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P58608}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Platymeris rhadamanthus (Red spot assassin bug)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav)..
U-reduvitoxin-Pr5a (U-RDTX-Pr5a)
insect
Venom Ptu1-like knottin family
Evidence at protein level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:31752210}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Venom Ptu1-like knottin family
U-reduvitoxin-Pr5a (U-RDTX-Pr5a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:31752210}.
insect