Back to search

Peptide record

TPDB72519

Neurotoxin standard
47 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72519
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 47-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
GVPCLCDSDGPSVRGNTLSGTVWVFGCPSGWHICTSDGPTIGSCCKK
Physicochemical Analysis
C203H315N57O65S6
AEQMY
G
4786.44
6.75
4
3
11
-0
3.35
0.057
57.87
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11375
237.65
17
Residue Composition
number
0
A
1
R
1
N
3
D
6
C
0
E
0
Q
8
G
1
H
2
I
2
L
2
K
0
M
1
F
4
P
6
S
4
T
2
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 3 C: 6 E: 0 Q: 0 G: 8 H: 1 I: 2 L: 2 K: 2 M: 0 F: 1 P: 4 S: 6 T: 4 W: 2 Y: 0 V: 4
Chemical Descriptors
47
C203H315N57O65S6
4786.44
6.75
-0
3.35
0.057
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to the sodium channels Nav1.1/SCN1A (EC(50)=453 nM), Nav1.5/SCN5A (EC(50)=440 nM) and Nav1.6/SCN8A (EC(50)=1740 nM), thereby delaying their inactivation (PubMed:21802465, Ref.1). Also inhibits Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.4/SCN4A, but to a lesser extent (PubMed:21802465). Toxin effect on Nav1.1 and Nav1.6 (and on Nav1.5, but in a lesser extent) consists in an incomplete inactivation (PubMed:21802465). {ECO:0000269|PubMed:20483220, ECO:0000269|PubMed:21802465, ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma cangicum (Sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to the sodium channels Nav1.1/SCN1A (EC(50)=453 nM), Nav1.5/SCN5A (EC(50)=440 nM) and Nav1.6/SCN8A (EC(50)=1740 nM), thereby delaying their inactivation (PubMed:21802465, Ref.1). Also inhibits Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.4/SCN4A, but to a lesser extent (PubMed:21802465).
Delta-actitoxin-Bcg1d (Delta-AITX-Bcg1d) (Delta-AITX-Bcg1a) (Delta-AITX-Bcg1b) (Delta-actitoxin-Bcg1e) (Delta-AITX-Bcg1e) (Toxin Bcg 30.24)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Bcg1d (Delta-AITX-Bcg1d) (Delta-AITX-Bcg1a) (Delta-AITX-Bcg1b) (Delta-actitoxin-Bcg1e) (Delta-AITX-Bcg1e) (Toxin Bcg 30.24)
sea anemone