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Peptide record

TPDB72517

Neurotoxin standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB72517
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 47-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
RGSVDYKDDDDKTISCTNPKQCYPHCKKETGYPNAKCMNRKCKCFGR
Physicochemical Analysis
C226H360N70O72S7
LW
K
5434.19
8.83
12
6
8
+5
17.35
-1.411
16.60
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
4845
89.16
18
Residue Composition
number
1
A
3
R
3
N
5
D
6
C
1
E
1
Q
3
G
1
H
1
I
0
L
8
K
1
M
1
F
3
P
2
S
3
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 3 D: 5 C: 6 E: 1 Q: 1 G: 3 H: 1 I: 1 L: 0 K: 8 M: 1 F: 1 P: 3 S: 2 T: 3 W: 0 Y: 3 V: 1
Chemical Descriptors
47
C226H360N70O72S7
5434.19
8.83
+5
17.35
-1.411
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of the A-type voltage-gated potassium channels. Most potent inhibitor of Kv1.2/KCNA2 channels. Reversibly block the Shaker B potassium-channels (Kv1.1 sub-family). {ECO:0000269|PubMed:8660410}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pandinus imperator (Emperor scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Potent inhibitor of the A-type voltage-gated potassium channels. Most potent inhibitor of Kv1.2/KCNA2 channels.
Potassium channel toxin alpha-KTx 7.1 (Pandinotoxin-alpha) (Potassium channel-blocking toxin 2) (Pi-2) (Pi2) (Toxin PiTX-K-alpha)
PTX-1
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 07 subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 8 fields
PTX-1
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 07 subfamily
Potassium channel toxin alpha-KTx 7.1 (Pandinotoxin-alpha) (Potassium channel-blocking toxin 2) (Pi-2) (Pi2) (Toxin PiTX-K-alpha)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion