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Peptide record

TPDB72513

Neurotoxin standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB72513
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 38-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
GVDKPGCRYMFGGCVQDDDCCPHLGCKRKGLYCAWDGT
Physicochemical Analysis
C175H265N51O53S7
NEIS
G
4155.76
6.75
6
5
10
-0
5.71
-0.463
38.42
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
213.08
10
Residue Composition
number
1
A
2
R
0
N
5
D
6
C
0
E
1
Q
7
G
1
H
0
I
2
L
3
K
1
M
1
F
2
P
0
S
1
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 5 C: 6 E: 0 Q: 1 G: 7 H: 1 I: 0 L: 2 K: 3 M: 1 F: 1 P: 2 S: 0 T: 1 W: 1 Y: 2 V: 2
Chemical Descriptors
38
C175H265N51O53S7
4155.76
6.75
-0
5.71
-0.463
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Paralytic toxin that inhibits insect voltage-gated sodium (Nav) and calcium (Cav) channels in P.americana (American cockroach) dorsal unpaired median (DUM) neurons, and inhibits the B.germanica (German cockroach) Nav channel (BgNaV1) (PubMed:28475112). Also shows a delay in fast inactivation when tested on BgNaV1 (PubMed:28475112). May act as a gating-modifier toxin on Nav and as a pore blocker on Cav (PubMed:28475112). In vivo, reversibly paralyzes both L.cuprina (Australian sheep blowfly) and M.domestica (housefly), but does not affect larvae of H.armigera (cotton bollworms) (PubMed:28475112). {ECO:0000269|PubMed:28475112}.

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Monocentropus balfouri (Socotra Island blue baboon tarantula)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Paralytic toxin that inhibits insect voltage-gated sodium (Nav) and calcium (Cav) channels in P.americana (American cockroach) dorsal unpaired median (DUM) neurons, and inhibits the B.germanica (German cockroach) Nav channel (BgNaV1) (PubMed:28475112). Also shows a delay in fast inactivation when tested on BgNaV1 (PubMed:28475112).
Mu/omega-theraphotoxin-Mb1a (Mu/omega-TRTX-Mb1a)
spider
Neurotoxin 10 (Hwtx-1) family, 28 (Jztx-11) subfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:28475112}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 28 (Jztx-11) subfamily
Mu/omega-theraphotoxin-Mb1a (Mu/omega-TRTX-Mb1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:28475112}.
spider