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Peptide record

TPDB72511

Neurotoxin standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB72511
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 13-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
YCCHPACGPNFSC
Physicochemical Analysis
C58H80N16O17S4
RDEQILKMTWV
C
1401.61
6.84
1
0
3
-0
-0.78
0.169
7.69
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1740
124.14
7
Residue Composition
number
1
A
0
R
1
N
0
D
4
C
0
E
0
Q
1
G
1
H
0
I
0
L
0
K
0
M
1
F
2
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C58H80N16O17S4
1401.61
6.84
-0
-0.78
0.169
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits fetal and adult muscle-type nAChR (IC(50)=52.1 nM towards alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND, and IC(50)=102.8 nM towards alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE). Shows potent activity on the synthetic AChR alpha-1-beta-1-delta/CHRNA1-CHRNB1-CHRND (IC(50)=16.9 nM). {ECO:0000269|PubMed:36292948}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus obscurus (Obscure cone) (Conus halitropus)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits fetal and adult muscle-type nAChR (IC(50)=52.1 nM towards alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND, and IC(50)=102.8 nM towards alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE).
Alpha-conotoxin OI (Alpha-conotoxin OIA)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:36292948}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin OI (Alpha-conotoxin OIA)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:36292948}.
cone snail