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Peptide record

TPDB72509

Neurotoxin standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB72509
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 40-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
SLFEFAKMILEETKRLPFPYYGAYGCYCGWGGQGQPKDAT
Physicochemical Analysis
C209H301N49O58S3
NHV
G
4524.16
6.39
4
4
16
-0
1.84
-0.403
46.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
11585
256.07
11
Residue Composition
number
3
A
1
R
0
N
1
D
2
C
3
E
2
Q
6
G
0
H
1
I
3
L
3
K
1
M
3
F
3
P
1
S
2
T
1
W
4
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 1 C: 2 E: 3 Q: 2 G: 6 H: 0 I: 1 L: 3 K: 3 M: 1 F: 3 P: 3 S: 1 T: 2 W: 1 Y: 4 V: 0
Chemical Descriptors
40
C209H301N49O58S3
4524.16
6.39
-0
1.84
-0.403
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. 10 ug/ml of this protein produce complete neuromuscular blockade up to 70 minutes, without inhibiting the responses to acetylcholine (ACh), but with a partial inhibition (67%) of the response to potassium chloride (KCl). {ECO:0000269|Ref.1}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedi pauloensis)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity. 10 ug/ml of this protein produce complete neuromuscular blockade up to 70 minutes, without inhibiting the responses to acetylcholine (ACh), but with a partial inhibition (67%) of the response to potassium chloride (KCl)..
Phospholipase A2 neuwieditoxin-2 (NeuTX-2) (PLA2) (EC 3.1.1.4) (Neuwieditoxin-II) (NeuTX-II) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Phospholipase A2 neuwieditoxin-2 (NeuTX-2) (PLA2) (EC 3.1.1.4) (Neuwieditoxin-II) (NeuTX-II) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake