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Peptide record

TPDB72506

Neurotoxin standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB72506
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 50-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MISMLRCTFFFLSVILITSYFVTPTMSIKCNCKRHVIKPHICRKICGKNG
Physicochemical Analysis
C260H426N70O62S8
ADEQW
I
5781.15
10.21
10
0
21
+8
1.15
0.544
95.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
30.10
16
Residue Composition
number
0
A
3
R
2
N
0
D
5
C
0
E
0
Q
2
G
2
H
7
I
3
L
5
K
3
M
4
F
2
P
4
S
4
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 0 C: 5 E: 0 Q: 0 G: 2 H: 2 I: 7 L: 3 K: 5 M: 3 F: 4 P: 2 S: 4 T: 4 W: 0 Y: 1 V: 3
Chemical Descriptors
50
C260H426N70O62S8
5781.15
10.21
+8
1.15
0.544
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent anti-inflammatory agent. At low concentrations, mediates the degranulation of mast cells thus evoking an inflammatory response. Also acts as a neurotoxin capable of blocking a class of voltage-gated potassium channels.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Apis mellifera (Honeybee)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Potent anti-inflammatory agent. At low concentrations, mediates the degranulation of mast cells thus evoking an inflammatory response.
Mast cell degranulating peptide (MCD peptide) (MCDP) (Peptide 401)
insect
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Formylation Ion channel impairing toxin Mast cell degranulation Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Disulfide bond Formylation Ion channel impairing toxin Mast cell degranulation Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Mast cell degranulating peptide (MCD peptide) (MCDP) (Peptide 401)
TISSUE SPECIFICITY: Expressed by the venom gland.
insect