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Peptide record

TPDB72505

Neurotoxin standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB72505
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 36-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
AGCKYLFGSCKEDSDCCKHLGCRRKAPQYCGWDGTF
Physicochemical Analysis
C172H258N50O51S6
NIMV
C
4034.61
8.02
7
4
9
+2
4.84
-0.636
27.22
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
8855
219.48
12
Residue Composition
number
2
A
2
R
0
N
3
D
6
C
1
E
1
Q
5
G
1
H
0
I
2
L
4
K
0
M
2
F
1
P
2
S
1
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 3 C: 6 E: 1 Q: 1 G: 5 H: 1 I: 0 L: 2 K: 4 M: 0 F: 2 P: 1 S: 2 T: 1 W: 1 Y: 2 V: 0
Chemical Descriptors
36
C172H258N50O51S6
4034.61
8.02
+2
4.84
-0.636
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin that targets voltage-gated sodium channels. Inhibits the inactivation of Nav1.7/SCN9A. {ECO:0000269|PubMed:32218140}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Poecilotheria vittata (Ghost ornamental tarantula) (Poecilotheria pederseni)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that targets voltage-gated sodium channels. Inhibits the inactivation of Nav1.7/SCN9A..
Beta/delta/mu-theraphotoxin-Pv1 (Beta/delta/mu-TRTX-Pv1) (Poecilotheriatoxin-1) (PcaTX-1)
spider
Neurotoxin 10 (Hwtx-1) family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32218140}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family
Beta/delta/mu-theraphotoxin-Pv1 (Beta/delta/mu-TRTX-Pv1) (Poecilotheriatoxin-1) (PcaTX-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:32218140}.
spider