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Peptide record

TPDB72504

Neurotoxin standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB72504
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 50-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
GCKGKYEECTRDSDCCDEKNRSGRKLRCLTQCDEGGCLKYRQCLFYGGLQ
Physicochemical Analysis
C233H376N74O78S8
AHIMPWV
C
5718.48
7.84
10
8
9
+2
16.10
-1.038
39.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4970
86.91
19
Residue Composition
number
0
A
5
R
1
N
4
D
8
C
4
E
3
Q
7
G
0
H
0
I
5
L
5
K
0
M
1
F
0
P
2
S
2
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 4 C: 8 E: 4 Q: 3 G: 7 H: 0 I: 0 L: 5 K: 5 M: 0 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 3 V: 0
Chemical Descriptors
50
C233H376N74O78S8
5718.48
7.84
+2
16.10
-1.038
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channels (Kv1/KCNA) (PubMed:23895459). Is potent on Drosophila Shaker IR channels (IC(50)=94.25 nM), and rKv1.2/KCNA2 (IC(50)=172.59 nM), and moderately active on hKv1.3/KCNA3 (IC(50)=1006.48 nM), rKv1.6/KCNA6 (IC(50)=2245.93 nM), and Kv1.1/KCNA1 (IC(50) around 3 uM) (PubMed:23895459). In vivo, induces a rapid increase in swimming speed on zebrafish larvae, as well as death which occurs between 2 and 18 hours later (By similarity). Also paralyzes swimming crabs (C.danae) when injected at the junction between the body and the walking leg (PubMed:23895459). {ECO:0000250|UniProtKB:A7RMN1, ECO:0000269|PubMed:23895459}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma caissarum (Sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits voltage-gated potassium channels (Kv1/KCNA) (PubMed:23895459). Is potent on Drosophila Shaker IR channels (IC(50)=94.25 nM), and rKv1.2/KCNA2 (IC(50)=172.59 nM), and moderately active on hKv1.3/KCNA3 (IC(50)=1006.48 nM), rKv1.6/KCNA6 (IC(50)=2245.93 nM), and Kv1.1/KCNA1 (IC(50) around 3 uM) (PubMed:23895459).
Kappa-actitoxin-Bcs4a (Kappa-AITX-Bcs4a) (Potassium channel toxin BcsTx3)
sea anemone
Sea anemone type 5 potassium channel toxin family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 5 potassium channel toxin family
Kappa-actitoxin-Bcs4a (Kappa-AITX-Bcs4a) (Potassium channel toxin BcsTx3)
sea anemone