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Peptide record

TPDB72499

Neurotoxin standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB72499
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 50-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
DLWQWGQMILKETGKLPFSYYTAYGCYCGWGGRGGKPKADTDRCCFVHDC
Physicochemical Analysis
C256H369N67O71S6
N
G
5713.51
7.72
7
5
17
+1
0.91
-0.516
41.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
22710
397.48
15
Residue Composition
number
2
A
2
R
0
N
4
D
5
C
1
E
2
Q
8
G
1
H
1
I
3
L
4
K
1
M
2
F
2
P
1
S
3
T
3
W
4
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 4 C: 5 E: 1 Q: 2 G: 8 H: 1 I: 1 L: 3 K: 4 M: 1 F: 2 P: 2 S: 1 T: 3 W: 3 Y: 4 V: 1
Chemical Descriptors
50
C256H369N67O71S6
5713.51
7.72
+1
0.91
-0.516
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that causes irreversible neuromuscular blockade in chick biventer cervicis muscle preparations. The neuromuscular blockade is mediated by inhibitory action at the presynaptic motor nerve endings. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|Ref.1}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bothrops marajoensis (Marajo lancehead)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that causes irreversible neuromuscular blockade in chick biventer cervicis muscle preparations. The neuromuscular blockade is mediated by inhibitory action at the presynaptic motor nerve endings.
Basic phospholipase A2 Bmaj-9 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Evidence at protein level
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Disulfide bond Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Basic phospholipase A2 Bmaj-9 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
snake