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Peptide record

TPDB72496

Neurotoxin standard
63 amino acids
Basic Information
3D PDB MODEL
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TPDB72496
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 63-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MGKLTILVLVAAALLSTQVMVQGDGDQPADRDAVPRDDNPSGMSGKFMNVLRRAGCPWDPWCG
Physicochemical Analysis
C290H466N84O88S6
EHY
DG
6729.76
4.64
6
7
26
-1
8.90
-0.087
80.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11125
165.31
12
Residue Composition
number
6
A
4
R
2
N
7
D
2
C
0
E
3
Q
7
G
0
H
1
I
6
L
2
K
4
M
1
F
5
P
3
S
2
T
2
W
0
Y
6
V
Amino Acid Distribution
A: 6 R: 4 N: 2 D: 7 C: 2 E: 0 Q: 3 G: 7 H: 0 I: 1 L: 6 K: 2 M: 4 F: 1 P: 5 S: 3 T: 2 W: 2 Y: 0 V: 6
Chemical Descriptors
63
C290H466N84O88S6
6729.76
4.64
-1
8.90
-0.087
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits high voltage-activated calcium channels (Cav). {ECO:0000269|PubMed:16945451}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus amadis (Amadis cone)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits high voltage-activated calcium channels (Cav)..
Contryphan-Am (Am975) (Bromocontryphan Ama1055) (Contryphan Am976) (Contryphan Ama976) [Cleaved into: Contryphan-Am Ama919 (Contryphan 919) (Contryphan-Am Am918)]
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation Bromination Calcium channel impairing toxin D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:16387709, ECO:0000305|PubMed:16945451, ECO:0000305|PubMed:17902199}.
Additional Detail Fields 7 fields
Amidation Bromination Calcium channel impairing toxin D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Contryphan-Am (Am975) (Bromocontryphan Ama1055) (Contryphan Am976) (Contryphan Ama976) [Cleaved into: Contryphan-Am Ama919 (Contryphan 919) (Contryphan-Am Am918)]
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:16387709, ECO:0000305|PubMed:16945451, ECO:0000305|PubMed:17902199}.
cone snail