TPDB

3D PDB MODEL

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TPDB ID TPDB72493

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 277-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MAVKGFRPTTPTRREMTMCTFEEITTSTPEKSLLVSLKKSGGRNANGKITVRHIGGGAKRKYRIIDFKRNKDNIPAKVVSIEYDPNRTAFIALVVYADGEKRYIIAPVGLKVGDTVVSGPESDIKVGNCLPIRNIPVGTVIHNIELAAGKGAQLVRSAGNSAQLMAKEGDYSQVRLPSGEVRYIRVECRATIGVVSNQTSEIVNIGKAGRKRHMGVRPTVRGSVMNPNDHPHGGGEGRSPIGHPSPRTPWGKPALGYKTRKNKKYSDRFIVKRRHDK

FASTA

>TPDB72493|Neurotoxin|length=277
MAVKGFRPTTPTRREMTMCTFEEITTSTPEKSLLVSLKKSGGRNANGKITVRHIGGGAKRKYRIIDFKRNKDNIPAKVVSIEYDPNRTAFIALVVYADGEKRYIIAPVGLKVGDTVVSGPESDIKVGNCLPIRNIPVGTVIHNIELAAGKGAQLVRSAGNSAQLMAKEGDYSQVRLPSGEVRYIRVECRATIGVVSNQTSEIVNIGKAGRKRHMGVRPTVRGSVMNPNDHPHGGGEGRSPIGHPSPRTPWGKPALGYKTRKNKKYSDRFIVKRRHDK

Formula C1327H2186N412O384S9

Absent Amino Acids

Common Amino Acids G

Mass 30345.03

PI 10.78

Basic Residues 57

Acidic Residues 23

Hydrophobic Residues 94

Net Charge +28

Boman Index 80.36

Hydrophobicity -0.539

Aliphatic Index 77.36

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 17545

Absorbance 280nm 57.82

Polar Residues 63

number

17

A

26

R

14

N

10

D

3

C

13

E

4

Q

30

G

7

H

21

I

11

L

24

K

6

M

5

F

18

P

17

S

17

T

1

W

8

Y

25

V

Amino Acid Distribution

A: 17 R: 26 N: 14 D: 10 C: 3 E: 13 Q: 4 G: 30 H: 7 I: 21 L: 11 K: 24 M: 6 F: 5 P: 18 S: 17 T: 17 W: 1 Y: 8 V: 25

Length

277

Formula

C1327H2186N412O384S9

Mass

30345.03

PI

10.78

Net Charge

+28

Boman Index

80.36

Hydrophobicity

-0.539

Evidence 1 Activity

Source & Reference

Database Source NA