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Peptide record

TPDB72489

Neurotoxin standard
63 amino acids
Basic Information
3D PDB MODEL
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TPDB72489
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 63-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKIFGLFLLIATYMALAFAGEDVCIPSGQKCGPYMNMGCCKGLVCMSYAARCVSMGGIPRMHI
Physicochemical Analysis
C298H476N76O77S13
W
G
6772.30
8.30
6
2
32
+3
-2.66
0.773
85.24
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
71.54
15
Residue Composition
number
6
A
2
R
1
N
1
D
6
C
1
E
1
Q
8
G
1
H
5
I
5
L
3
K
7
M
3
F
3
P
3
S
1
T
0
W
3
Y
3
V
Amino Acid Distribution
A: 6 R: 2 N: 1 D: 1 C: 6 E: 1 Q: 1 G: 8 H: 1 I: 5 L: 5 K: 3 M: 7 F: 3 P: 3 S: 3 T: 1 W: 0 Y: 3 V: 3
Chemical Descriptors
63
C298H476N76O77S13
6772.30
8.30
+3
-2.66
0.773
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P58608}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Platymeris rhadamanthus (Red spot assassin bug)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav)..
U-reduvitoxin-Pr4a (U-RDTX-Pr4a)
insect
Venom Ptu1-like knottin family
Evidence at protein level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:31752210}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Venom Ptu1-like knottin family
U-reduvitoxin-Pr4a (U-RDTX-Pr4a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:31752210}.
insect