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Peptide record

TPDB72485

Neurotoxin standard
78 amino acids
Basic Information
3D PDB MODEL
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TPDB72485
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 78-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKEANTRRYIHLCLVVVLVSTIITTEAEDDRLFCIRHHKYCGHRPNRCCSGLFCRCNTFGTNCRCQSKGALGKLISGK
Physicochemical Analysis
C377H618N120O106S10
W
C
8848.39
9.03
17
5
25
+8
14.56
-0.169
78.72
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3480
39.33
26
Residue Composition
number
3
A
8
R
4
N
2
D
9
C
3
E
1
Q
6
G
4
H
5
I
7
L
5
K
1
M
3
F
1
P
4
S
6
T
0
W
2
Y
4
V
Amino Acid Distribution
A: 3 R: 8 N: 4 D: 2 C: 9 E: 3 Q: 1 G: 6 H: 4 I: 5 L: 7 K: 5 M: 1 F: 3 P: 1 S: 4 T: 6 W: 0 Y: 2 V: 4
Chemical Descriptors
78
C377H618N120O106S10
8848.39
9.03
+8
14.56
-0.169
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable neurotoxin (Probable). Strongly inhibits voltage-gated potassium channels (Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3, and Kv1.6/KCNA6) and mildly inhibits sodium channels (Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, and BgNav). Induces activation of protein kinase A type II (PKA-II) and MAP kinase Erk1/2 in primary nociceptive and non-nociceptive sensory neurons. Does not show cytotoxic activity. Does not have an impact on Ca2+, cAMP, and NO signaling in the cell types analyzed. Does not interfere with the adhesion of leukocytes to endothelial cells (By similarity). {ECO:0000250|UniProtKB:P0DRI9, ECO:0000305|PubMed:24132120}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Xibalbanus tulumensis (Blind cave remipede) (Speleonectes tulumensis)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Probable neurotoxin (Probable). Strongly inhibits voltage-gated potassium channels (Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3, and Kv1.6/KCNA6) and mildly inhibits sodium channels (Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, and BgNav).
Xibalbin-13 1 (Xib13 1) (Kappa-speleotoxin(13)-Xt1a) (Kappa-SLTX(13)-Xt1a) (Putative neurotoxin)
contig00124
other
Xibalbin-13 family
Evidence at transcript level
Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:24132120}.
Additional Detail Fields 8 fields
contig00124
Amidation Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Xibalbin-13 family
Xibalbin-13 1 (Xib13 1) (Kappa-speleotoxin(13)-Xt1a) (Kappa-SLTX(13)-Xt1a) (Putative neurotoxin)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:24132120}.
other